Journal: Pharmaceutics

Article Title: Fast-Fed Variability: Insights into Drug Delivery, Molecular Manifestations, and Regulatory Aspects

doi: 10.3390/pharmaceutics14091807

Figure Lengend Snippet: Formulation strategies to overcome fast-fed variability: prodrugs, cyclodextrins, osmotic delivery systems, amorphous solid dispersions, nanocrystal technology, and lipid-based systems.

Article Snippet: 23. , Triglide ® , Fenofibrate , Nanocrystal , Skye Pharma Inc., San Diego, CA, USA.

Techniques: Formulation

Journal: Pharmaceutics

Article Title: Fast-Fed Variability: Insights into Drug Delivery, Molecular Manifestations, and Regulatory Aspects

doi: 10.3390/pharmaceutics14091807

Figure Lengend Snippet: Marketed formulations with innovators who have successfully diminished fast-fed variability.

Article Snippet: 23. , Triglide ® , Fenofibrate , Nanocrystal , Skye Pharma Inc., San Diego, CA, USA.

Techniques: Drug Formulation, Dispersion, Formulation

Journal: Pharmaceutics

Article Title: Fast-Fed Variability: Insights into Drug Delivery, Molecular Manifestations, and Regulatory Aspects

doi: 10.3390/pharmaceutics14091807

Figure Lengend Snippet: Comparison of mean plasma concentrations of MK-0869 after oral dosing in beagle dogs ( n = 5) of suspension (●, fasted; o, fed) with NanoCrystal ® dispersion formulation (▾, fasted; ▿, fed). Reprinted with permission from Ref. . Copyright 2004, Elsevier.

Article Snippet: 23. , Triglide ® , Fenofibrate , Nanocrystal , Skye Pharma Inc., San Diego, CA, USA.

Techniques: Comparison, Clinical Proteomics, Suspension, Dispersion, Formulation

Journal: Pharmaceutics

Article Title: Fast-Fed Variability: Insights into Drug Delivery, Molecular Manifestations, and Regulatory Aspects

doi: 10.3390/pharmaceutics14091807

Figure Lengend Snippet: Formulation approaches for reducing fast-fed state variability with pharmacokinetic data.

Article Snippet: 23. , Triglide ® , Fenofibrate , Nanocrystal , Skye Pharma Inc., San Diego, CA, USA.

Techniques: Formulation, Dispersion

Journal: Pharmaceutics

Article Title: Fast-Fed Variability: Insights into Drug Delivery, Molecular Manifestations, and Regulatory Aspects

doi: 10.3390/pharmaceutics14091807

Figure Lengend Snippet: Patents filed exclusively to reduce fast-fed variability.

Article Snippet: 23. , Triglide ® , Fenofibrate , Nanocrystal , Skye Pharma Inc., San Diego, CA, USA.

Techniques: Formulation, Dispersion, Membrane, Emulsion

Journal: Pharmaceutics

Article Title: Fast-Fed Variability: Insights into Drug Delivery, Molecular Manifestations, and Regulatory Aspects

doi: 10.3390/pharmaceutics14091807

Figure Lengend Snippet: Formulation strategies to overcome fast-fed variability: prodrugs, cyclodextrins, osmotic delivery systems, amorphous solid dispersions, nanocrystal technology, and lipid-based systems.

Article Snippet: 21. , Lipantil Supra ® , Fenofibrate , Nanocrystal , AbbVie Inc. North Chicago, IL, USA.

Techniques: Formulation

Journal: Pharmaceutics

Article Title: Fast-Fed Variability: Insights into Drug Delivery, Molecular Manifestations, and Regulatory Aspects

doi: 10.3390/pharmaceutics14091807

Figure Lengend Snippet: Marketed formulations with innovators who have successfully diminished fast-fed variability.

Article Snippet: 21. , Lipantil Supra ® , Fenofibrate , Nanocrystal , AbbVie Inc. North Chicago, IL, USA.

Techniques: Drug Formulation, Dispersion, Formulation

Journal: Pharmaceutics

Article Title: Fast-Fed Variability: Insights into Drug Delivery, Molecular Manifestations, and Regulatory Aspects

doi: 10.3390/pharmaceutics14091807

Figure Lengend Snippet: Comparison of mean plasma concentrations of MK-0869 after oral dosing in beagle dogs ( n = 5) of suspension (●, fasted; o, fed) with NanoCrystal ® dispersion formulation (▾, fasted; ▿, fed). Reprinted with permission from Ref. . Copyright 2004, Elsevier.

Article Snippet: 21. , Lipantil Supra ® , Fenofibrate , Nanocrystal , AbbVie Inc. North Chicago, IL, USA.

Techniques: Comparison, Clinical Proteomics, Suspension, Dispersion, Formulation

Journal: Pharmaceutics

Article Title: Fast-Fed Variability: Insights into Drug Delivery, Molecular Manifestations, and Regulatory Aspects

doi: 10.3390/pharmaceutics14091807

Figure Lengend Snippet: Formulation approaches for reducing fast-fed state variability with pharmacokinetic data.

Article Snippet: 21. , Lipantil Supra ® , Fenofibrate , Nanocrystal , AbbVie Inc. North Chicago, IL, USA.

Techniques: Formulation, Dispersion

Journal: Pharmaceutics

Article Title: Fast-Fed Variability: Insights into Drug Delivery, Molecular Manifestations, and Regulatory Aspects

doi: 10.3390/pharmaceutics14091807

Figure Lengend Snippet: Patents filed exclusively to reduce fast-fed variability.

Article Snippet: 21. , Lipantil Supra ® , Fenofibrate , Nanocrystal , AbbVie Inc. North Chicago, IL, USA.

Techniques: Formulation, Dispersion, Membrane, Emulsion

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: SERS involves inelastic light scattering by molecules adsorbed onto corrugated metal surfaces such as silver or gold nanoparticles.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques:

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: Structures ranging from nanogap geometry (NPoM) to nanoparticle sensing using CB:AuNP aggregates enable surface-enhanced Raman scattering applications from single-molecule detection to personalized medicine.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques:

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: Total interaction pair potentials between two (···) Au@TA, (- - -) Au@MHA, and (—) Au@MUA nanoparticles predicted using xDLVO theory. Reproduced from ref . Copyright 2015 American Chemical Society.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques:

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: Self-organized gold nanoparticle layers as surface-enhanced Raman scattering substrates. (a) TEM images of hexagonally packed gold nanoparticles in a monolayer (left), bilayer (middle), and trilayer (right). BM–bright mode, DM–dark mode. (b) Absorption spectra and plasmon eigenmodes of the gold layers shown in (a). (c) Raman spectrum of polystyrene measured on the monolayer (black) and the bilayer (red). The 5–10 increase in total scattering intensity corresponds to ∼10 4 enhancement of the Raman cross section. Adapted with permission from refs ( and ). Copyrights 2018 American Chemical Society and 2019 Royal Society of Chemistry, respectively.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques:

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: SEM (a, b) and TEM (c) images of HP modified with two bilayers of gold nanoparticles. (d) Photographs of dispersions of LbL-modified HPs with gold layer thickness increasing from left to right, in 1 M NaCl. (e, f) Confocal microscopy images of Au-coated HPs (e) and polystyrene beads (f), in 1 M NaCl. Adapted from ref . Copyright 2018 American Chemical Society.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques: Modification, Confocal Microscopy

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: (a) Background-corrected Raman scattering intensity of various AuNP-modified HPs for detection of 1 μM methylene blue with increasing loading of AuNPs; one bilayer (blue), one bilayer with salt (red), two bilayers with salt (black). (b) Raman scattering spectra obtained with HP (black) and polystyrene beads (red) modified with two bilayers of gold nanoparticles of 1 μM MB and 1 μM R6G in TSB. Adapted from ref . Copyright 2018 American Chemical Society.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques: Modification

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: Comparison of spectral emission profiles: fluorescence from Cy5 and SERS from 4-NTB on Au nanoparticles excited with 632.8 nm laser radiation. Reproduced with permission from ref . Copyright 2014 Royal Society of Chemistry.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques: Fluorescence

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: ( a ) (i) SEM, (ii) scattering, and (iii) Raman images of a nanoparticle-coupled nanowire plasmonic waveguide for remote SERS. The green cross in (iii) marks the illumination position. Reprinted from ref . Copyright 2009 American Chemical Society. ( b ) (i) Transmission and (ii) remote SERS images of a live HeLa cell with the nanoparticle-coupled nanowire endoscopy. (iii) The SERS spectrum from the nucleus region of the cell. Reprinted with permission from ref . Copyright 2014 Wiley-VCH.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques: Transmission Assay

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: (A) SEM images of a typical nanorod supercrystal island film and SERS spectra of (a) natural and (b) spiked human blood; (c) natural and (d) spiked human plasma. (e) SERS spectra spiked human plasma after spectral subtraction of the matrix (human plasma). (f) SERS spectra of the scrambled prion. Adapted with permission from ref . Copyright 2011 National Academy of Sciences. (B) SERS of 141-nucleobase ssDNA fragment of the wild-type K-Ras gene and with different single-point mutations and its classification by using partial least-squares discriminant analysis. Adapted with permission from ref . Copyright 2017 Wiley-VCH. (C) SERS detection of the oncoprotein c-MYC. The sensor includes a specific peptide (H1) for c-MYC chemically attached to an optical molecular spring (mercapto- N -methylbenzamide, MMB), which is bound to a silver nanoparticle. Theoretical and experimental Raman spectrum of MMB and SERS spectra of MMB, MB-H1, and MB-H1 in the presence of c-MYC, on SiO 2 @Ag. Magnification of the spectral windows between 730–800 and 990–1050 cm –1 are also shown. (C–B) Model used in the estimation of the molecular orientation. Absolute orientation of the molecule on the surface and relative orientation of the ring over the surface are represented by XYZ and xyz axes, respectively. Adapted from ref . Copyright 2016 American Chemical Society.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques:

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: (A). Operating principle of the iMS detection approach (“Off-to-On” scheme). The “stem-loop” DNA probe of the iMS, having a Raman label at one end of the stem, is immobilized onto a metallic nanoparticle or nanostar via a metal–thiol bond. In the absence of the target, the probe is “open” with very low SERS signal (“Off” state). Upon exposure to a target sequence, the target first binds to the toehold region (intermediate I) and starts displacing the DNA probe from the placeholder via branch migration (intermediate II), finally releasing the placeholder from the nanoparticle system. This enables the stem-loop to “close” and brings the Raman label closer to the plasmonic metal surface, producing a strong SERS signal (“On” state). Adapted from ref . Copyright 2016 American Chemical Society. (B) Nanowave platform consisting of nanosphere arrays coated with a silver film. Adapted from ref . Copyright 1984 American Chemical Society. The inset represents the unit cell used as a 3D model for finite element modeling calculations. Adapted from ref . Copyright 2012 American Chemical Society. (C) AFM image of a bimetallic Nanowave chip used for detection of Dengue nucleic acid biotargets. Adapted with permission from ref . Copyright 2014 Royal Society of Chemistry. (D) Synthesis of cubic nanorattles to be used in an integrated “lab-in-a-stick” device. TEM images of (E) AuNP; (F) AuNP@AgCube; (G) reporter-loaded AuNP@CubeCage; (H) cube nanorattles. Adapted with permission from ref . Copyright 2018 Springer Nature.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques: Sequencing, Migration

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: (A) SERS active gold nanostar dimer for mercury ion detection (top) and gold nanoparticle–nanorod heteroassemblies for bisphenol A detection (bottom). Adapted with permission from refs ( and ). Copyrights 2013 Royal Society of Chemistry and 2016, Elsevier B. V., respectively. (B) SERS active gold nanorod assembly for toxin detection. Adapted with permission from ref . Copyright 2012 Royal Society of Chemistry. (C) Plasmonic nanoparticle heterochains and SERS enhancement properties. Adapted from ref . Copyright 2013 American Chemical Society.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques:

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: (a) SERS detection of 1-naphtol using core–shell Au@poly( N -isopropylacryamide) colloids. Reproduced with permission from ref . Copyright 2009 Wiley-VCH. (b) Plasmonic thin films fabricated through LbL assemby of Au nanoparticles and ammonium pillar[5]arene (AP[5]A) for (multiplexed) SERS sensing of PAHs in gas or liquid phase. Reproduced from ref . Copyright 2017 American Chemical Society. (c) ZIF8-coated silver film over nanospheres for the detection of benzene, toluene, nitrobenzene, or 2,6-di- tert -butylpyridine in gas phase. Reproduced with permission from ref . Copyright 2014 Royal Society of Chemistry.

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques:

Journal: ACS Nano

Article Title: Present and Future of Surface-Enhanced Raman Scattering

doi: 10.1021/acsnano.9b04224

Figure Lengend Snippet: Components of SERS Nanotags with Some Examples

Article Snippet: To overcome this limitation, Tian’s group developed so-called shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS).

Techniques: